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Auf der folgenden Seite finden Sie unsere wissenschaftlichen Forschungsergebnisse, die, auf Grundlage einer unabhängigen Gutachtermasse, geprüft und anschließend veröffentlicht worden sind. Dabei legen wir besonderen Wert auf die Einhaltung der Prinzipien guter wissenschaftliche Praxis sowie der freien Verfügbarkeit unserer Wissenschaft.

2023

12/2023

Holistic bursting cells store long-term memory in auditory cortex

Nat Comm
Li R, Huang J, Li L, Zhao Z, Liang S, Liang S, Wang M, Liao X, Lyu J, Zhou Z, Wang S, Jin W, Chen H, Holder D, Liu H, Zhang J, Li M, Tang Y, Remy S, Pakan JMP, Chen X, Jia H
10/2023

Changes in cortical microstructure of the human brain resulting from long-term motor learning

J Neurosci
Lehmann N, Aye N, Kaufmann J, Heinze H-J, Düzel E, Ziegler G, Taubert M
08/2023

Medical and Behavioral Knowledge Discovery using Multi-Objective Analysis

IEEE CIBCB 2023: Conference on Computational Intelligence in Bioinformatics and Computational Biology
Mostaghim S, Shan Q, Desel C, Duscha A, Haghikia A, Hegelmeier T, Kuhn F, Remy S
07/2023

A cost-based multi-layer network approach for the discovery of patient phenotypes

Int J Data Sci Anal
Puga C, Niemann U, Schlee W, Spiliopoulou M
06/2023

Inferring Salient Motifs during Learning Experiments

2023 IEEE 36th International Symposium on Computer-Based Medical Systems (CBMS)
Jamaludeen N, Kuhn F, Brechmann A, Fuhrmann F, Remy S, Spiliopoulou M
06/2023

Effects of transcutaneous auricular vagus nerve stimulation paired with tones on electrophysiological markers of auditory perception

Brain Stimul
Rufener KS, Wienke C, Salanje A, Haghikia A, Zähle T
05/2023

A shift in the mechanisms controlling hippocampal engram formation during brain maturation

Science
Ramsaran AI, Wang Y, Golbabaei A, Aleshin S, de Snoo ML, Yeung BA, Rashid AJ, Awasthi A, Lau J, Tran LM, Ko SY, Abegg A, Duan LC, McKenzie C, Gallucci J, Ahmed M, Kaushik R, Dityatev A, Josselyn SA, Frankland PW
05/2023

Rescue of synaptic and cognitive functions in polysialic acid-deficient mice and dementia models by short polysialic acid fragments

Neurobiol Dis
Varbanov H, Jia S, Kochlamazashvili G, Bhattacharya S, Buabeid MA, El Tabbal M, Hayani H, Stoyanov S, Sun W, Thiesler H, Röckle I, Hildebrandt H, Senkov O, Suppiramaniam V, Gerardy-Schahn R, Dityatev A
04/2023

Effects of repetitive twice-weekly transcranial direct current stimulations on fatigue and fatigability in people with multiple sclerosis

Sci Rep
Linnhoff S, Haghikia A, Zähle T
03/2023

Open-source tools for behavioral video analysis: Setup, methods, and best practices

eLIFE
Luxem K, Sun SJ, Bradley SP, Krishnan K, Yttri E, Zimmermann J, Pereira TD, Laubach M
03/2023

A hippocampus-accumbens code guides goal-directed appetitive behavior

bioRxiv
Barnstedt O, Mocellin P, Remy S
03/2023

Holistic Bursting Cells Store Long-term Memory in Auditory Cortex

PREPRINT from Research Square
Li R, Huang J, Liang S, Liang S, Wang M, Liao X, Lyu J, Zhou Z, Jin W, Chen H, Holder D, Liu H, Zhang J, Li M, Tang Y, Remy S, Pakan J, Chen X, Jia H
02/2023

Modelling the contributions to hyperexcitability in a mouse model of Alzheimer's disease

The Journal of Physiology
Mittag M, Mediavilla L, Remy S, Cuntz H, Jedlicka P
02/2023

Jacob-induced transcriptional inactivation of CREB promotes Aβ-induced synapse loss in Alzheimer's disease

EMBO J
Grochowska KM, Gomes GM, Raman R, Kaushik R, Sosulina L, Kaneko H, Oelschlegel AM, Yuanxiang P, Reyes-Resina I, Bayraktar G, Samer S, Spilker C, Woo MS, Morawski M, Goldschmidt J, Friese MA, Rossner S, Navarro G, Remy S, Reissner C, Karpova A, Kreutz MR
01/2023

The therapeutic potential of non-invasive brain stimulation for the treatment of Long-COVID-related cognitive fatigue

Front Immunol
Linnhoff S, Köhler L, Haghikia A, Zähle T
01/2023

Cognitive fatigue-related sensory gating deficits in people with multiple sclerosis

Neurobiol Dis
Linnhoff S, Haghikia A, Zähle T
01/2023

Fatigability-related oscillatory brain activity changes in people with MS

Mult Scler Relat Disord
Linnhoff S, Haghikia A, Zähle T

2022

11/2022

Unsupervised mobile app-based cognitive testing in a population-based study of older adults born 1944

Front. Digit. Health
Öhman F, Berron D, Papp KV, Kern S, Skoog J, Hadarsson Bodin T, Zettergren A, Skoog I, Schöll M
11/2022

Identifying behavioral structure from deep variational embeddings of animal motion

Commun Biol
Luxem K, Mocellin P, Fuhrmann F, Kürsch J, Miller SR, Palop JJ, Remy S, Bauer P
10/2022

Transversal functional connectivity and scene-specific processing in the human entorhinal-hippocampal circuitry

eLife
Grande X, Sauvage M, Becke A, Düzel E, Berron D
08/2022

Exploring Dynamic Pandemic Containment Strategies Using Multi-Objective Optimization

IEEE Computational Intelligence Magazine
Fischer D, Mostaghim S, Seidemann T
07/2022

Multi-Objective Evolutionary Game Theory: A case study in cancer therapy

ALIFE 2022: The 2022 Conference on Artificial Life
Bostelmann-Arp L, Mostaghim S, Braun A, Tüting T
07/2022

The metabolic profile of reconstituting T-cells, NK-cells, and monocytes following autologous stem cell transplantation and its impact on outcome

Sci Rep
Richter S, Böttcher M, Völkl S, Mackensen A, Ullrich E, Jacobs B, Mougiakakos D
06/2022

When Can I Expect the mHealth User to Return? Prediction Meets Time Series with Gaps

Artificial Intelligence in Medicine: 20th International Conference on Artificial Intelligence in Medicine, AIME 2022
Schleicher M, Pryss R, Schlee W and Spiliopoulou M
05/2022

Feasibility of digital memory assessments in an unsupervised and remote study setting

Front. Digit. Health
Berron D, Ziegler G, Vieweg P, Billette O, Güsten J, Grande X, Heneka MT, Schneider A, Teipel S, Jessen F, Wagner M, Duzel E
03/2022

Brain Activation During Active Balancing and Its Behavioral Relevance in Younger and Older Adults: A Functional Near-Infrared Spectroscopy (fNIRS) Study

Front Aging Neurosci
Lehmann N, Kuhn YA, Keller M, Aye N, Herold F, Draganski B, Taube W, Taubert M
03/2022

Type 1 innate lymphoid cells regulate the onset of Toxoplasma gondii-induced neuroinflammation

Cell Reports
Steffen J, Ehrentraut S, Bank U, Biswas A, Figueiredo CA, Hölsken O, Düsedau HP, Dovhan V, Knop L, Thode J, Romero-Suárez S, Duarte CI, Gigley J, Romagnani C, Diefenbach A, Klose CSN, Schüler T, Dunay IR
02/2022

Path integration in normal aging and Alzheimer’s disease

Trends in Cognitive Sciences
Vladislava Segen, Johnson Ying, Erik Morgan, Mark Brandon, Thomas Wolbers

2021

12/2021

Path integration in normal aging and Alzheimer's disease

Trends in Cognitive Sciences
Segen V, Ying J, Morgan E, Brandon M, Wolbers T
11/2021

Amplitude Modulated Transcranial Alternating Current Stimulation (AM-TACS) efficacy evaluation via phosphene induction

Sci Rep
Thiele C, Zähle T, Haghikia A, Ruhnau P
11/2021

Making the rich richer: Frontoparietal tDCS enhances transfer effects of a single-session distractor inhibition training on working memory in high capacity individuals but reduces them in low capacity individuals

NeuroImage
Schmicker M, Menze I, Schneider C, Taubert M, Zähle T, Mueller NG
10/2021

Early Stages of Tau Pathology and its Associations with Functional Connectivity, Atrophy and Memory

Brain
Berron D, Vogel JW, Insel PS, Pereira JB, Xie L, Wisse LEM, Yushkevich PA, Palmqvist S, Mattsson-Carlgren N, Stomrud E, Smith R, Strandberg O, Hansson O
10/2021

Current challenges in reliably targeting the noradrenergic locus coeruleus using transcutaneous auricular vagus nerve stimulation (taVNS)

Autonomic Neuroscience
Ludwig M, Wienke C, Betts MJ, Zaehle T, Hämmerer D
10/2021

Context value updating and multidimensional neuronal encoding in the retrosplenial cortex

Nat Commun
Sun W, Choi I, Stoyanov S, Senkov O, Ponimaskin E, Winter Y, Pakan JMP, Dityatev A
07/2021

Current advances in digital cognitive assessment for preclinical Alzheimer’s disease

Alzheimers Dement (Amst)
Öhman F, Hassenstab J, Berron D, Schöll M, Papp KV
07/2021

Effects of transcutaneous vagus nerve stimulation (tVNS) on beta and gamma brain oscillations

Cortex
Keute M, Wienke C, Ruhnau P, Zähle T
07/2021

Objective electrophysiological fatigability markers and their modulation through tDCS

Clin Neurophysiol
Linnhoff S, Wolter-Weging J, Zähle T
06/2021

Transcutaneous vagus nerve stimulation in patients with attention-deficit/ hyperactivity disorder: a viable option?

Prog Brain Res
Zähle T, Krauel K
06/2021

Dysfunctional auditory gamma oscillations in developmental dyslexia - a potential target for a tACS-based intervention

Prog Brain Res
Rufener KS, Zähle T
05/2021

Non-invasive, opsin-free mid-infrared modulation activates cortical neurons and accelerates associative learning

Nat Commun
Zhang J, He Y, Liang S, Liao X, Li T, Qiao Z, Chang C, Jia H, Chen X
05/2021

The complement system drives local inflammatory tissue priming by metabolic reprogramming of synovial fibroblasts

Immunity
Friščić J, Böttcher M, Reinwald C, Bruns H, Wirth B, Popp SJ, Walker KI, Ackermann JA, Chen X, Turner J, Zhu H, Seyler L, Euler M, Kirchner P, Krüger R, Ekici AB, Major T, Aust O, Weidner D, Fischer A, Andes FT, Stanojevic Z, Trajkovic V, Herrmann M, Korb-Pap A, Wank I, Hess A, Winter J, Wixler V, Distler J, Steiner G, Kiener HP, Frey B, Kling L, Raza K, Frey S, Kleyer A, Bäuerle T, Hughes TR, Grüneboom A, Steffen U, Krönke G, Croft AP, Filer A, Köhl J, Klein K, Buckley CD, Schett G, Mougiakakos D, Hoffmann MH
04/2021

Increased hippocampal excitability and altered learning dynamics mediate cognitive mapping deficits in human aging

JNeurosci
Diersch N, Valdes-Herrera JP, Tempelmann C, Wolbers T
04/2021

Frontal Transcranial Direct Current Stimulation as a Potential Treatment of Parkinson’s Disease-Related Fatigue

Brain Sci
Zähle T
02/2021

Associations of Plasma Phospho-Tau217 Levels With Tau Positron Emission Tomography in Early Alzheimer Disease

JAMA Neurol
Janelidze S, Berron D, Strandberg O, Proctor NK, Dage JL, Smith R, Stomrud E, Palmqvist S, Mattsson Carlgren N, Hansson O

2020

12/2020

The internal time keeper: causal evidence for the role of the cerebellum in anticipating regular acoustic events

Cortex
Rufener KS, Husemann A, Zähle T
12/2020

The role of the gut microbiota and microbial metabolites in neuroinflammation

Eur J Immunol
Haase S, Wilck N, Haghikia A, Gold R, Mueller DN, Linker RA
11/2020

Transcranial direct current stimulation (tDCS) over the auditory cortex modulates GABA and Glutamate – a 7 Tesla MR-spectroscopy study

Sci Rep
Heimrath K, Brechmann A, Blobel-Lüer R, Stadler J, Budinger E, Zähle T
08/2020

Pulsed transcranial electric brain stimulation enhances speech comprehension

Brain Stimul
Ruhnau P, Rufener KS, Heinze HJ, Zähle T
07/2020

Multiple sclerosis and nutrition: back to the future?

Ther Adv Neurol Disord
Gold R, Montalban X, Haghikia A
05/2020

Reward Association Enhances Stimulus-Specific Representations in Primary Visual Cortex

Current Biology
Henschke JU, Dylda E, Katsanevaki D, Dupuy N, Currie SP, Amvrosiadis T, Pakan JMP, Rochefort NL
04/2020

Medial Temporal Lobe Connectivity and its Associations with Cognition in Early Alzheimer’s Disease

Brain
Berron D, van Westen D, Ossenkoppele R, Strandberg S, Hansson O
04/2020

Converging patterns of aging-associated brain volume loss and tissue microstructure differences

NeuroBiol Aging
Taubert M, Roggenhofer E, Melie-Garcia L, Muller S, Lehmann N, Preisig M, Vollenweider P, Marques-Vidal P, Lutti A, Kherif F, Draganski B
04/2020

Inconsistent effects of stochastic resonance on human auditory processing

Sci Rep
Rufener KS, Kauk J, Ruhnau P, Repplinger S, Heil P, Zähle T
03/2020

Co-Localized White Matter Plasticity And Increased Cerebral Blood Flow Mediate The Beneficial Effect Of Cardiovascular Exercise On Long-Term Motor Learning

J Neurosci
Lehmann N, Villringer A, & Taubert M
03/2020

Propionic Acid Shapes the Multiple Sclerosis Disease Course by an Immunomodulatory Mechanism

Cell
Duscha A, Gisevius B, Hirschberg S, Yissachar N, Stangl GI, Eilers E, Bader V, Haase S, Kaisler J, David C, Schneider R, Troisi R, Zent D, Hegelmaier T, Dokalis N, Gerstein S, Del Mare-Roumani S, Amidror S, Staszewski O, Poschmann G, Stuhler K, Hirche F, Balogh A, Kempa S, Trager P, Zaiss MM, Holm JB, Massa MG, Nielsen HB, Faissner A, Lukas C, Gatermann SG, Scholz M, Przuntek H, Prinz M, Forslund SK, Winklhofer KF, Muller DN, Linker RA, Gold R, Haghikia A
03/2020

Matching stimulation paradigms resolve apparent differences between optogenetic and electrical VTA stimulation

Brain Stimul
Weidner TC, Vincenz D, Brocka M, Tegtmeier J, Oelschlegel AM, Ohl FW, Goldschmidt J, Lippert MT
02/2020

c-FLIP is crucial for IL-7/IL-15-dependent NKp46+ ILC development and protection from intestinal inflammation in mice

Nat Commun
Bank U, Deiser K , Plaza-Sirvent C, Osbelt L, Witte A, Knop L, Labrenz R, Jänsch R, Richter F, Biswas A, Zenclussen AC, Vivier E, Romagnani C, Kühl AA, Dunay IR, Strowig T, Schmitz I, Schüler T

2019

10/2019

Single-cell memory trace imaging with immediate-early genes

J Neurosci Methods
Sauvage M, Kitsukawa T, Atucha E
09/2019

Hierarchical network analysis of behavior and neuronal population activity

CCN 2019: 2019 Conference on Cognitive Computational Neuroscience
Luxem K, Fuhrmann F, Remy S, Bauer P
08/2019

No modulation of pupil size and event-related pupil response by transcutaneous auricular vagus nerve stimulation (taVNS)

Sci Rep
Keute M, Demirezen M, Graf A, Mueller N, Zähle T
06/2019

Transcranial electrical stimulation improves phoneme processing in developmental dyslexia

Brain Stimul
Rufener KS, Krauel K, Meyer M, Heinze HJ, Zähle T
05/2019

Cognitive Fatigue in Multiple Sclerosis: An Objective Approach to Diagnosis and Treatment by Transcranial Electrical Stimulation

Brain Sci
Linnhoff S, Fiene M, Heinze HJ, Zähle T
05/2019

A novel immunoregulatory function of beta-2-microglobulin as a promoter of myeloid derived suppressor cell induction

Leukemia
Bruns H, Jitschin S, Gamali S, Saul D, Böttcher M, Mackensen A, Jitschin R, Mougiakakos D
02/2019

The potential of virtual reality for spatial navigation research across the adult lifespan

J Exp Biol.
Diersch N, Wolbers T
02/2019

Offline impact of transcranial focused ultrasound on cortical activation in primates

eLife
Verhagen L, Gallea C, Folloni D, Constans C, Jensen DE, Ahnine H, Roumazeilles L, Santin M, Ahmed B, Lehericy S, Klein-Flügge MC, Krug K, Mars RB, Rushworth MF, Pouget P, Aubry JF, Sallet J
02/2019

Interferon-γ Receptor Signaling in Dendritic Cells Restrains Spontaneous Proliferation of CD4+ T Cells in Chronic Lymphopenic Mice

Front Immunol
Knop L, Frommer C, Stoycheva D, Deiser K, Kalinke U, Blankenstein T, Kammertoens T, Dunay IR, Schüler T

2018

03/2018

Caldendrin Directly Couples Postsynaptic Calcium Signals to Actin Remodeling in Dendritic Spines

Neuron
Mikhaylova M, Bär J, van Bommel B, Schätzle P, YuanXiang P, Raman R, Hradsky J, Konietzny A, Loktionov EY, Reddy PP, Lopez-Rojas J, Spilker C, Kobler O, Raza SA, Stork O, Hoogenraad CC, Kreutz MR
02/2018

FISSA: A neuropil decontamination toolbox for calcium imaging signals

Scientific Reports
Keemink SW, Lowe SC, Pakan JMP, Dylda E, van Rossum MCW, Rochefort NL
01/2018

Dietary fatty acids and susceptibility to multiple sclerosis

Mult Scler
Haase S, Haghikia A, Gold R, Linker RA

2017

12/2017

Septo-hippocampal interaction

Cell Tissue Res
Müller C, Remy S
01/2017

Optogenetic Destabilization of the Memory Trace in CA1: Insights into Reconsolidation and Retrieval Processes

Cereb Cortex
Lux V, Masseck OA, Herlitze S, Sauvage MM

2016

11/2016

Glutamatergic synaptic integration of locomotion speed via septoentorhinal projections

Nat Neurosci
Justus D, Dalügge D, Bothe S, Fuhrmann F, Hannes C, Kaneko H, Friedrichs D, Sosulina L, Schwarz I, Elliott DA, Schoch S, Bradke F, Schwarz MK, Remy S
09/2016

Dysfunction of Somatostatin-Positive Interneurons Associated with Memory Deficits in an Alzheimer's Disease Model

Neuron
Schmid LC, Mittag M, Poll S, Steffen J, Wagner J, Geis HR, Schwarz I, Schmidt B, Schwarz MK, Remy S, Fuhrmann M
06/2016

Rapid and Specific Grey Matter Changes Induced by Balance Training

NeuroImage
Taubert M, Mehnert J, Pleger B, Villringer A

2015

10/2015

Dietary Fatty Acids Directly Impact Central Nervous System Autoimmunity via the Small Intestine

Immunity
Haghikia A, Jorg S, Duscha A, Berg J, Manzel A, Waschbisch A, Hammer A, Lee DH, May C, Wilck N, Balogh A, Ostermann AI, Schebb NH, Akkad DA, Grohme DA, Kleinewietfeld M, Kempa S, Thone J, Demir S, Muller DN, Gold R, Linker RA
06/2015

Acetylcholine mediates behavioral and neural post-error control

Curr Biol
Danielmeier C, Allen EA, Jocham G, Onur OA, Eichele T, Ullsperger M
01/2015

IFN-γ regulates CD8+ memory T cell differentiation and survival in response to weak, but not strong, TCR signals

J Immunol
Stoycheva D, Deiser K, Stärck L, Nishanth G, Schlüter D, Uckert W, Schüler T

2014

12/2014

Dendritic structural degeneration is functionally linked to cellular hyperexcitability in a mouse model of Alzheimer's disease

Neuron
Šišková Z, Justus D, Kaneko H, Friedrichs D, Henneberg N, Beutel T, Pitsch J, Schoch S, Becker A, von der Kammer H, Remy S
09/2014

Dendritic inhibition mediated by O-LM and bistratified interneurons in the hippocampus

Front Synaptic Neurosci
Müller C, Remy S
01/2014

Structural brain plasticity in Parkinson's disease induced by balance training

Neurobiology of Ageing
Sehm B, Taubert M, Conde V, Weise D, Classen J, Dukart J, Draganski B, Villringer A, Ragert P

2013

02/2013

Encoding and transducing the synaptic or extrasynaptic origin of NMDA receptor signals to the nucleus

Cell
Karpova A, Mikhaylova M, Bera S, Bär J, Reddy PP, Behnisch T, Rankovic V, Spilker C, Bethge P, Sahin J, Kaushik R, Zuschratter W, Kähne T, Naumann M, Gundelfinger ED, Kreutz MR

2012

09/2012

Inhibitory control of linear and supralinear dendritic excitation in CA1 pyramidal neurons

Neuron
Müller C, Beck H, Coulter D, Remy S

2011

08/2011

Long-term effects of motor training on resting-state networks and its underlying brain structure

NeuroImage
Taubert M, Lohmann G, Margulies DS, Villringer A, Ragert P

2010

09/2010

Dynamic properties of human brain structure: learning-related changes in cortical areas and associated fiber connections

J Neurosci
Taubert M, Draganski B, Anwander A, Müller K, Horstmann A, Villringer A, Ragert P
03/2010

IFN-gamma receptor signaling regulates memory CD8+ T cell differentiation

J Immunol
Sercan O, Stoycheva D, Hämmerling GJ, Arnold B, Schüler T

2006

01/2006

Innate immune cells contribute to the IFN-gamma-dependent regulation of antigen-specific CD8+ T cell homeostasis

J Immunol
Sercan O, Hämmerling GJ, Arnold B, and Schüler T
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