Workspace
Recovery Promotion
The severity and chronicity of cognitive dysfunction caused by bodily diseases and adverse events is moderated by the ability of the brain to recover. This workspace will investigate key recovery mechanisms including recuperation from neural exhaustion and brain clearance with special emphasis on pathological fatigue.
'Many factors from the environment and the body can influence the brain's ability to regenerate. Knowing these influencing factors will help us avoid the negative factors and target the positive ones for therapy.'
For the last decade, we investigated the impact of environmental factors on brain health and disease with special emphasis on identifying components originating from dietary habits and involvement of the human gut microbiome. In a translational study, where we supplemented short-chained fatty acids (SCFA) in healthy controls and 300 MS patients for up to three years, we detected a substantial immunomodulatory mechanism driven by SCFA with dist...
In the context of growing skill shortages, maintaining the health of the workforce is becoming increasingly important. Besides physical illnesses, mental health disorders, in particular, contribute to a rising number of absence days. To counter this, our project aims to address the following key aspects: the objective measurement and evaluation of cognitive fatigue in the workplace, the impact of assistive technologies, and the translation of ...
Systemic immune surveillance requires highly mobile immune cells with varying tissue tropisms. For example, naïve T cells (TN) circulate between lymph nodes (LNs) while effector T cells (TE) migrate to the site of infection to produce microbicidal effector molecules such as Interferon-γ (IFN-γ). After pathogen clearance a small fraction of TE converts into long-lived circulating memory T cells (TCIRCM) and tissue-resident memory T cells (TRM)....
Fatigue, being a subjective perception, poses a diagnostic challenge due to its intangible nature. It afflicts approximately 80%, of individuals with MS, detrimentally impacting their overall quality of life. Nonetheless, the understanding of and therapeutic interventions for fatigue in MS remain limited. Objective fatigability, which represents a quantifiable decline in performance, also coexists alongside subjective fatigue. However, the exp...
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How do our brains, our bodies and our environment interact? How do physical illnesses affect our mental performance? And why are we more efficient on some days than others?
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