Platforms

INFRASTRUCTURE, TOOLBOX AND STUDIES

SUPPORTSYSTEMS

We advance the multi-scale investigation of neurocognitive circuits across different species by cross-cutting interactions of our three platforms with our workspaces and hence, uncover mechanisms of cognitive vitality. We are uniquely equipped to identify causal relationships from circuits to behaviour in different models and transfer these principles to the human brain. In these innovative collaboration structures, we make use of our methodological expertise in brain imaging and computational modelling. The Middle-Elbe platform, thereby, implements proof-of-concept studies allowing forward and reverse translation from clinical research and care.

Our transdisciplinary research is interconnected by the major topics of identifying circuit mechanisms, their vulnerabilities and mechanisms of reserve. This understanding will relate circuit level mechanisms to key cognitive deficits and provide prognostic and interventional strategies in the future.

aUFZEICHNUNG, BILDGEBUNG, EINFLUSS NEHMEN

NEUROKOGNITIVE SCHALTKREISE

Die Plattform "Neurokognitive Schaltkreise" wird auf der einzigartigen Expertise in den Bereichen Bildgebung und Elektrophysiologie aufbauen, um neue Methoden für die kausale Untersuchung von NCCs in verschiedenen Tiermodellen und Menschen zu entwickeln und ihre Wirksamkeit von Zellen bis Verhalten zu belegen. Unser methodisches Portfolio umfasst 2-Photonen-Bildgebung und Neurostimulation sowie kombinierte maschinelle Lernansätze zur Verhaltensquantifizierung von Interventionen. Wir werden neue Methoden für die schichtauflösende MRT und Konnektivitätsanalyse entwickeln und MR-PET-Liganden für die molekulare Bildgebung von synaptischer Dichte und Entzündung etablieren.

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Computational Intelligence for Cognitive Vitality

DECODE Platform

The main goal of the Data Science and Computational Modelling (DECODE) platform is to promote and disseminate cross-sectional research for Cognitive Vitality. The challenges in cognitive vitality are so complex, that out-of-the-box learning algorithms cannot be applied. Recent advances in data-driven learning, including cutting edge methodologies of computational intelligence (CI) and data science, together with powerful computing resources have pushed the boundaries towards solving challenging real problems of complex systems. More than ever, we can unleash the potential of such methodolo...

Middle-Elbe Platform

Cognitive vitality is the ability to mobilise and use the brain's potential in everyday life. It is a prerequisite for a self-realised and independent life and is essentially determined by the interaction of mental resources, physical stressors and environmental factors. In order to understand which neuronal and physical mechanisms limit individual resources, reduce them in the case of illness and protect them from the negative effects of illness and stress factors, we are building an observation and intervention platform - the Middle Elbe Intervention Platform. The knowledge gained from th...