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Real-world Participation

Real-world participation (RWP) comprises fundamental human activities such as engaging in societal activities, roaming through novel places and experiencing stimulation by cultural activities and at work. Since preserving RWP is key for maintaining cognitive vitality across the lifespan, this workspace will characterise how neurocognitive circuits involved in cognitive, sensorimotor and emotional processing affect - and are affected by - activities of real-world participation.

FROM THE INNER EAR TO EVERYDAY VITALITY AND BACK

EXPLORING THE NEXUS OF HEARING LOSS, ALZHEIMER'S DISEASE AND MEMORY DECLINE

In this workspace we implement interdisciplinary approaches to enable multipronged studies spanning multiple levels of analysis. We investigate (i) how age-related vestibular degeneration affects spatial coding, subjective fear and ultimately, real-world mobility. With innovative combinations of participatory design, immersive virtual reality, and ultra-high resolution neuroimaging, we elucidate structural and functional alterations from the inner ear to the entorhinal-hippocampal circuit and assess the rehabilitative potential of extended reality (XR) technologies. We will (ii) decipher the impact of hearing loss and its interaction with Alzheimer’s pathology on the functional and structural integrity of the human medial temporal lobe and memory. Using neuroimaging, we will investigate whether hearing restoration can normalize these neurocognitive circuits, increase social participation in the real world, and prevent long-term cognitive decline. Given that postural deficits can impede real-world participation of older adults, we will (iii) employ adaptive postural training and longitudinal neuroimaging to investigate the impact of RWP and associated cognitive vitality on neural reserve capacity. We will focus on reserve mechanisms such as cortical morphology and microstructural plasticity that can enable older people to cope with challenging postural situations.

Bridging the gap between fundamental neurocognitive circuits and real-world behavior will yield important insights on how we can preserve functional independence and cognitive vitality in everyday life.

Prof. Dr. Thomas Wolbers

From vestibular degeneration to alterations in spatial coding fear perception and ...

Vestibular perception begins to decline at the age of 40, and vertigo and dizziness, resulting from vestibular dysfunction, are among the most common complaints in humans over 60. Vestibular dysfunction in aging adults is further associated with a higher risk of falls, lower quality of life and a decrease in cognitive function. In this project, we will determine how theoretically motivated Extended Reality (XR) can be used to counteract age-re...

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UNDERSTANDING THE IMPACT OF HEARING LOSS ON COGNITIVE DECLINE

Hearing loss is a major risk factor for cognitive decline and dementia. Given that there is an overlap in the neural cognitive circuits involved in episodic memory and auditory pattern analysis critical to hearing, we hypothesize that the effects of hearing loss and the parallel accumulation of Alzheimer's pathology might accelerate cognitive decline. In addition, hearing loss is associated with social isolation, which in itself can lead to fu...

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INCREASING REAL-WORLD PARTICIPATION AND COGNITIVE VITALITY THROUGH POSTURAL TRAINING

Maintaining postural control is an automated but highly demanding task for the brain that requires the integration of various sensory information and predictive motor processing. In addition, postural deficits limit real-world participation, which can be seen, for example, in the limitations of patients with vestibular symptoms. Therefore, postural deficits can have a negative impact on cognition, either directly through reduced demands on the...

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Joining forces across disciplines

Our
Workspaces

The overarching goal of our research cluster is to understand, treat and prevent cognitive impairment. Hence, we designed four strategically and thematically related workspaces which together cover manifold aspects of cognitive vitality.

Our workspaces stand for innovative collaboration structures on the principles of neurocognitive circuit research and convergence. Within we bring together the fields of cognitive neuroscience, clinical medicine, and engineering/informatics which leads to research on fundamental mechanisms and their translation into clinical applications and technology.

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Real-world Participation

Brain Protection

Resource Mobilisation

Recovery Promotion

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How do our brains, our bodies and our environment interact? How do physical illnesses affect our mental performance? And why are we more efficient on some days than others?
We would like to get to the bottom of these questions together with you. Register now and take part in exciting studies.

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Otto-von-Guericke-Universität
Institut für Kognitive Neurologie und Demenzforschung
‍
Leipziger Straße 44, 39120 Magdeburg
Contact
Heike Sommermeier
+49 391 67 25476 heike.sommermeier@med.ovgu.de
Judith Wesenberg
+49 391 67 25061 judith.wesenberg@med.ovgu.de
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