UNDERSTANDING THE IMPACT OF HEARING LOSS ON COGNITIVE DECLINE

WHY IS HEARING LOSS ASSOCIATED WITH COGNITIVE DECLINE

RESTORATION AND PREVENTION

Hearing loss is a major risk factor for cognitive decline and dementia. Given that there is an overlap in the neural cognitive circuits involved in episodic memory and auditory pattern analysis critical to hearing, we hypothesize that the effects of hearing loss and the parallel accumulation of Alzheimer's pathology might accelerate cognitive decline. In addition, hearing loss is associated with social isolation, which in itself can lead to future cognitive decline. Using high-resolution imaging, measurements of Alzheimer's disease pathology, and digital and remote measurements of cognition and participation in the real world, we aim to understand the complex relationship between hearing loss and cognitive decline.

What we want to achieve

Our Project Goals

Develop screening strategy for hearing loss in real-world settings

Characterizing the structural integrity of the medial temporal lobe and in individuals with hearing loss and Alzheimer’s disease pathology

Investigating the functional integrity of the medial temporal lobe in individuals with hearing loss and Alzheimer’s disease pathology

Determine mid-term MTL-related cognitive decline using smartphone-based cognitive assessments

Identify measures of real-world social participation using experience sampling and ambulatory assessments

EVALUATE

We want to evaluate the impact of hearing restoration on measures of medial temporal lobe integrity, social participation and cognitive decline.

Project Team

Dr. David Berron

Prof. Dr. Martin Durisin

Prof. Dr. Tömme Noesselt

Publications

11/2022

Unsupervised mobile app-based cognitive testing in a population-based study of older adults born 1944

Front. Digit. Health

Öhman F, Berron D, Papp KV, Kern S, Skoog J, Hadarsson Bodin T, Zettergren A, Skoog I, Schöll M

10/2022

Transversal functional connectivity and scene-specific processing in the human entorhinal-hippocampal circuitry

eLife

Grande X, Sauvage M, Becke A, Düzel E, Berron D

05/2022

Feasibility of digital memory assessments in an unsupervised and remote study setting

Front. Digit. Health

Berron D, Ziegler G, Vieweg P, Billette O, Güsten J, Grande X, Heneka MT, Schneider A, Teipel S, Jessen F, Wagner M, Duzel E

10/2021

Early Stages of Tau Pathology and its Associations with Functional Connectivity, Atrophy and Memory

Brain

Berron D, Vogel JW, Insel PS, Pereira JB, Xie L, Wisse LEM, Yushkevich PA, Palmqvist S, Mattsson-Carlgren N, Stomrud E, Smith R, Strandberg O, Hansson O

07/2021

Current advances in digital cognitive assessment for preclinical Alzheimer’s disease

Alzheimers Dement (Amst)

Öhman F, Hassenstab J, Berron D, Schöll M, Papp KV

02/2021

Associations of Plasma Phospho-Tau217 Levels With Tau Positron Emission Tomography in Early Alzheimer Disease

JAMA Neurol

Janelidze S, Berron D, Strandberg O, Proctor NK, Dage JL, Smith R, Stomrud E, Palmqvist S, Mattsson Carlgren N, Hansson O

04/2020

Medial Temporal Lobe Connectivity and its Associations with Cognition in Early Alzheimer’s Disease

Brain

Berron D, van Westen D, Ossenkoppele R, Strandberg S, Hansson O

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